12/20/2023 0 Comments Cell membrane structure downloadAlthough this diagram presents possible mechanisms of integral membrane protein mobility restraint, it does not accurately represent the sizes and structures of integral membrane proteins, lipid domains, or membrane-associated cytoskeletal structures. In addition, membrane-associated cytoskeletal structures are indirectly interacting with integral membrane proteins at the inner membrane surface along with matrix or ECM components at the outer surface. The cell membrane has been peeled back at the right to reveal the bottom membrane surface and membrane-associated cytoskeletal elements that form barriers (corrals) that limit the lateral motions of some of the integral membrane proteins. A, a representation of the cell membrane that contains membrane domain structures and membrane-associated cytoskeletal and extracellular structures. ©2015 AACR.Ī hypothetical cancer cell undergoing change to an invasive phenotype and beginning the process of invasion. In addition, components can be released from cells as secretory molecules, enzymes, receptors, large macromolecular complexes, membrane vesicles, and exosomes that can modify the microenvironment, provide specific cross-talk, and facilitate invasion, survival, and growth of malignant cells. These associations may be altered in malignant cells, and probably also in surrounding normal cells, promoting invasion and metastatic colonization. In describing the macrostructure and dynamics of plasma membranes, membrane-associated cytoskeletal structures and extracellular matrix are also important, constraining the motion of membrane components and acting as traction points for cell motility. More recent information has shown the importance of specialized membrane domains, such as lipid rafts, protein–lipid complexes, receptor complexes, invadopodia, and other cellular structures in the malignant process. Over the years, data have accumulated on the amounts, structures, and mobilities of membrane constituents after transformation and during progression and metastasis. This structure forms because of the physical properties of its constituents, which can move laterally and selectively within the membrane plane and associate with similar or different constituents, forming specific, functional domains. Cancer cells are surrounded by a fluid–mosaic membrane that provides a highly dynamic structural barrier with the microenvironment, communication filter and transport, receptor and enzyme platform.
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